metagenome / metatranscriptome analysis
Understanding the microbiome immune-inflammation axis is becoming more and more important for drug discovery and development for several therapeutic areas and may ultimately lead to microbiome-derived companion diagnostics
In addition, understanding microbiome-drug interaction is another element to Precision Medicine
We are offering state of the art technologies to address these questions
Targeted MGX
- High-throuput sequencing on Illna MiSeq platform
- Amplicon-based appraoch
- Targets:
- 16S region for bacterial profiling
- ITS region for fungal profiling
Whole MGX sequencing
- Shot-gun sequencing of while metagonome
- Ollumina NovaSeq platform
- De-novo assembly
- Metatranscriptome sequencing for metabolic profiling
Bacterial Load
- Absolute qualification of bacterial sequences
- qPCR-based approach on ViiA7 platform (ABI)
- For quantitative interpretation of targeted MGx results
application examples
PROGNOSTIC MICROBIOME PROFILING OF STOOL SAMPLES
MICROBIOME PROFILING OF TREATED SKIN SAMPLES
MICROBIOME PROFILING OF STOOL SAMPLES
PATHOGEN SCREENING
PROGNOSTIC MICROBIOME PROFILING OF STOOL SAMPLES
- Analysis of intestinal microbial diversity
- Profiling due to cohorts, due to treatment, over time
- High-level data analysis and data integration
MICROBIOME PROFILING OF TREATED SKIN SAMPLES
- Analysis of skin microbial diversity
- Profiling of different skin areas, before/after application
- High-level data analysis and data integration
MICROBIOME PROFILING OF STOOL SAMPLES
- Functional/metabolic potential of the microbiome
- Profiling on cohorts, due to treatment, over time
- High-level data analysis and data integration
- Drug validation
PATHOGEN SCREENING
- Screening of cell cultures/tissues for viral/bacterial contamination
- High-level data analysis and data integration
- QC for therapeutic production lines
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