metagenome / metatranscriptome analysis
Understanding the microbiome immune-inflammation axis is becoming more and more important for drug discovery and development for several therapeutic areas and may ultimately lead to microbiome-derived companion diagnostics
In addition, understanding microbiome-drug interaction is another element to Precision Medicine
We are offering state of the art technologies to address these questions
Targeted MGX
- High-throuput sequencing on Illna MiSeq platform
- Amplicon-based appraoch
- Targets:
- 16S region for bacterial profiling
- ITS region for fungal profiling
Whole MGX sequencing
- Shot-gun sequencing of while metagonome
- Ollumina NovaSeq platform
- De-novo assembly
- Metatranscriptome sequencing for metabolic profiling
Bacterial Load
- Absolute qualification of bacterial sequences
- qPCR-based approach on ViiA7 platform (ABI)
- For quantitative interpretation of targeted MGx results
application examples
PROGNOSTIC MICROBIOME PROFILING OF STOOL SAMPLES
- Analysis of intestinal microbial diversity
- Profiling due to cohorts, due to treatment, over time
- High-level data analysis and data integration
MICROBIOME PROFILING OF TREATED SKIN SAMPLES
- Analysis of skin microbial diversity
- Profiling of different skin areas, before/after application
- High-level data analysis and data integration
MICROBIOME PROFILING OF STOOL SAMPLES
- Functional/metabolic potential of the microbiome
- Profiling on cohorts, due to treatment, over time
- High-level data analysis and data integration
- Drug validation
PATHOGEN SCREENING
- Screening of cell cultures/tissues for viral/bacterial contamination
- High-level data analysis and data integration
- QC for therapeutic production lines
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